The neurosocial phenotype of the Triplex X Syndrome

Triple X syndrome (47,XXX) occurs with a frequency of 1:800 to 1:1000 in girls, although it is possible that the syndrome is not diagnosed due to the often inconspicuous symptomatology. Although there are some anecdotal reports of abnormalities in social interaction (e.g., in the regulation of closeness and distance and the decoding of social signals), and affected individuals and their relatives report problems in everyday social life, no systematic studies regarding socio-cognitive and socio-affective characteristics are available to date. Therefore, the present study aims at the cognitive, affective and behavioral characterization of women with 47,XXX in the context of social interactions. Another goal is to explore neural structural correlates of the presumed socio-cognitive features using functional and structural MRI. In addition to morphometric investigations, the focus will also be on investigations of structural connectivity.

Duration: 01/21 - 11/23
Funding: Internal
Contact: Jobst Meyer, Marie-Anne Croyé, Gregor Domes
in collaboration with  Prof. med. Winfried Willinek (BKT)