Genetic variation of the GR might be one of the factors underlying individual susceptibility to stress related disorders. In a growing number of studies, common polymorphisms of NR3C1 have been associated with variability in sensitivity to GCs, changes in metabolic parameters and HPA axis responses to psychosocial stress.
We performed functional characterization of NR3C1 variants in the 5´-regulatory region and investigate polymorphisms wtih respect to behavioral traits and disorders.
Own publications on the subject:
Schote AB, Bonenberger M, Pálmason H, Seitz C, Meyer J, Freitag CM, Glucocorticoid receptor variants in childhood attention-deficit/hyperactivity disorder and comorbid psychiatric disorders, Psychiatry Research, Volume 246, 30 December 2016, Pages 275-283
Li-Tempel T, Larra MF, Sandt E, Mériaux SB, Schote AB, Schächinger H, Muller CP, Turner JD. The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation. Clin Epigenetics. 2016 Jan 28;8:12
Schneider KK, Frings C, Meyer J, Schote AB. The role of the glucocorticoid receptor gene (NR3C1) for the processing of aversive stimuli. Neurosci Res. 2016 Jun;107:8-13
Kumsta R.*, Moser D.*, Streit F., Koper J.W., Meyer J. and Wüst S. (accepted for publication 6/2008): Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics *these authors contributed equally