Publikationen

2019

Schellenberger MT, Bock U, Hennen J, Groeber-Becker F, Walles H, Blömeke B. In Press. A coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals after topical exposure. Toxicology in Vitro. doi:10.1016/j.tiv.2019.02.002

Chary A, Serchi T, Moschini E, Hennen J, Cambier S, Ezendam J, Blomeke B, Gutleb AC. 2019. An in vitro coculture system for the detection of sensitization following aerosol exposure. ALTEX. doi: 10.14573/altex.1901241

2018

Hennen J, Blömeke B. 2018. Ranking skin-sensitizing hair dye molecules according to their potency by the use of human cells. Contact Dermatitis. doi: 10.1111/cod.13094

Schuttelaar ML, Dittmar D, Burgerhof JGM, Blömeke B, Goebel C. 2018. Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine in p-phenylenediamine-allergic individuals: Results from open use testing and diagnostic patch testing. Contact Dermatitis. doi: 10.1111/cod.13078

Goebel C, Diepgen TL, Blömeke B, Gaspari AA, Schnuch A, Fuchs A, Schlotmann K, Krasteva M, Kimber I. 2018. Skin sensitization quantitative risk assessment for occupational exposure of hairdressers to hair dye ingredients. Regul Toxicol Pharmacol 95:124-132. doi: 10.1016/j.yrtph.2018.03.006

Coenraads PJ, Aberer W, Cristaudo A, Diepgen T, Holden C, Koch L, Schuttelaar ML, Weisshaar E, Fuchs A, Schlotmann K, Goebel C, Blömeke B, Krasteva M. 2018. The Allergy Alert Test: Introduction of a Protocol Suitable to Provide an Alert Signal in p-Phenylenediamine-Allergic Hair Dye Users. Dermatitis. doi: 10.1097/DER.0000000000000405

Chary A, Hennen J, Klein SG, Serchi T, Gutleb AC, Blömeke B. 2018. Respiratory sensitization: toxicological point of view on the available assays. Arch Toxicol 92(2):803-822. doi: 10.1007/s00204-017-2088-5

2017

van Vliet E, Kuhnl J, Goebel C, Martinozzi-Teissier S, Alepee N, Ashikaga T, Blömeke B, Del Bufalo A, Cluzel M, Corsini E and others. 2017. State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop. ALTEX. doi: 10.14573/altex.1709011

Hennen, J., and Blömeke, B. (2017). 'Assessment of skin sensitization potency of hair dye molecules in vitro', in Contact Dermatitis. p 7. PMID: 27768804

Lichter J, Golka K, Sim E, Blömeke B. 2017. Recent progress in N-acetyltransferase research: 7th international workshop on N-acetyltransferases (NAT): workshop report. Arch Toxicol. PMID: 28331975

Klein SG, Cambier S, Hennen J, Legay S, Serchi T, Nelissen I, Chary A, Moschini E, Krein A, Blömeke B and others. 2017. Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter. Part Fibre Toxicol 14(1):7. PMID: 28264691

Hennen J, Blömeke B. 2017. Keratinocytes improve prediction of sensitization potential and potency of chemicals with THP-1 cells. ALTEX 34(2):279-288. PMID: 27768804

2016

Zahir A, Kindred C, Blömeke B, Goebel C, Gaspari AA. 2016. Tolerance to a Hair Dye Product Containing 2-Methoxymethyl-P-Phenylenediamine in an Ethnically Diverse Population of P-Phenylenediamine-Allergic Individuals. Dermatitis 27(6):355-361. doi: 10.1097/DER.0000000000000230. PMID: 27775972

Lichter J, Bock U, Lotz C, Groeber F, Blömeke B. 2016. Functional expression of N-acetyltransferase 1 (NAT1) in differentiated human skin keratinocytes. Br J Dermatol. doi: 10.1111/bjd.15091. PMID: 27681044

Kock M, Coenraads PJ, Blömeke B, Goebel C. 2016. Continuous usage of a hair dye product containing 2-methoxymethyl-p-phenylenediamine by hair dye allergic individuals. Br J Dermatol 174(5):1042-50. PMID: 26749506

Coenraads PJ, Vogel TA, Blömeke B, Goebel C, Roggeband R, Schuttelaar MLA. 2016. The role of the antioxidant ascorbic acid in the elicitation of contact allergic reactions to p‐phenylenediamine. Contact dermatitis 74(5):267-72. PMID: 26875881

Pot LM, Coenraads PJ, Blömeke B, Puppels GJ, Caspers PJ. 2016. Real-time detection of p-phenylenediamine penetration into human skin by in vivo Raman spectroscopy. Contact Dermatitis 74(3):152-8. PMID: 26778536

2015

Krutz NL, Hennen J, Korb C, Schellenberger MT, Gerberick GF, Blömeke B. 2015. Activation of the Endoperoxide Ascaridole Modulates Its Sensitizing Capacity. Toxicol Sci 147(2):515-23. PMID: 26185204

Blömeke B, Pot LM, Coenraads PJ, Hennen J, Kock M, Goebel C. 2015. Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals. Br J Dermatol 172(4):976-80. PMID: 25234507

Luyts K, Napierska D, Dinsdale D, Klein SG, Serchi T, Hoet PH. 2015. A coculture model of the lung-blood barrier: the role of activated phagocytic cells. Toxicol In Vitro 29(1):234-41. PMID: 25448809

Pot LM, Coenraads PJ, Goebel C, Blömeke B. 2014. Assessment of the elicitation response in subjects weakly sensitized to p-phenylenediamine. Br J Dermatol 172(1):138-44. PMID: 24890083

Bonifas J, Blomeke B. 2015. N-acetylation of aromatic amines: Implication for skin and immune cells. Front Biosci (Elite Ed) 7:305-21. PMID: 25553379

2014

Balszuweit F, Menacher G, Bloemeke B, Schmidt A, Worek F, Thiermann H, Steinritz D. 2014. Development of a co-culture of keratinocytes and immune cells for in vitro investigation of cutaneous sulfur mustard toxicity. Chem Biol Interact 223(0):117-124. PMID: 25256379

Christoffers WA, Blömeke B, Coenraads PJ, Schuttelaar ML. 2014. The optimal patch test concentration for ascaridole as a sensitizing component of tea tree oil. Contact Dermatitis 71(3):129-37. PMID: 24645715

Gundert-Remy U, Bernauer U, Blömeke B, Döring B, Fabian E, Goebel C, Hessel S, Jäckh C, Lampen A, Oesch F, Petzinger E, Volkel W, Roos PH. 2014. Extrahepatic metabolism at the body's internal-external interfaces. Drug Metab Rev 46(3):291-324. PMID: 24666398

Georgantzopoulou A, Skoczynska E, Van den Berg JH, Brand W, Legay S, Klein SG, Rietjens IM, Murk AJ. 2014. P-gp efflux pump inhibition potential of common environmental contaminants determined in vitro. Environ Toxicol Chem 33(4):804-13. PMID: 24375866

Goebel C, Troutman J, Hennen J, Rothe H, Schlatter H, Gerberick GF, Blömeke B. 2014. Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction. Toxicol Appl Pharmacol 274(3):480-7. PMID: 24333256

2013

Klein SG, Serchi T, Hoffmann L, Blomeke B, Gutleb AC. 2013. An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung. Part Fibre Toxicol 10(1):31. PMID: 23890538

Hennen J, Blömeke B. 2013. Verbesserte Aktivierung und Detektion von Prohaptenen in einer Ko-Kultur. BIOspektrum 19(4):376-378.

Pot LM, Scheitza SM, Coenraads P-J, Blömeke B. 2013. Penetration and haptenation of p-phenylenediamine. Contact Dermatitis 68(4):193-207. PMID: 23510340

Christoffers WA, Blomeke B, Coenraads PJ, Schuttelaar ML. 2013. Co-sensitization to ascaridole and tea tree oil. Contact Dermatitis 69(3):187-9. PMID: 23948040

2012

 

 

Goebel C, Diepgen TL, Krasteva M, Schlatter H, Nicolas J-F, Blömeke B, Coenraads PJ, Schnuch A, Taylor JS, Pungier J, Fautz R, Fuchs A, Schuh W, Gerberick GF, Kimber I. 2012. Quantitative risk assessment for skin sensitisation: Consideration of a simplified approach for hair dye ingredients. Regul Toxicol Pharmacol 64(3):459-465. PMID: 32069142

Scheitza S, Bonifas J, Blomeke B. 2012. Variable NAT1 Enzyme Activity in Long-Term Cultured Human HaCaT Keratinocytes. J Toxicol Environ Health A 75(8-10):471-7. PMID: 22686306

Kalmes M, Blomeke B. 2012. Impact of Eugenol and Isoeugenol on AhR Translocation, Target Gene Expression, and Proliferation in Human HaCaT Keratinocytes. J Toxicol Environ Health A 75(8-10):478-91. PMID: 22686307

Dierolf D, Scheitza S, Bonifas J, Blomeke B. 2012. Cyanamide-mediated Inhibition of N-acetyltransferase 1. Toxicology 302(1):1-10. PMID: 22835378

 

1991-2011

Klein SG, Hennen J, Serchi T, Blomeke B, Gutleb AC. 2011. Potential of coculture in vitro models to study inflammatory and sensitizing effects of particles on the lung. Toxicol In Vitro 25(8):1516- 34. PMID: 21963807

Hennen J, Aeby P, Goebel C, Schettgen T, Oberli A, Kalmes M, Blömeke B. 2011. Cross Talk between Keratinocytes and Dendritic Cells: Impact on the Prediction of Sensitization. Toxicol Sci 123(2):501-10. PMID: 21742781

Bakker CV, Blömeke B, Coenraads P-J, Schuttelaar M-L. 2011. Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients. Contact Dermatitis 65(4):240-1. PMID: 21906073

Kalmes M, Hennen J, Clemens J, Blömeke B. 2011. Impact of aryl hydrocarbon receptor (AhR) knockdown on cell cycle progression in human HaCaT keratinocytes. Biol Chem 392:643–651. PMID: 21627536

Pot LM, Alizadeh BZ, Ahrenberg D, Coenraads PJ, Snieder H, Blomeke B. 2011. No major role for glutathione S-transferase gene polymorphisms in sensitization to para-phenylenediamine and other xenobiotics; a study of association and a meta-analysis. Br J Dermatol 164:878–899. PMID: 21198535

Goebel C, Coenraads PJ, Rothe H, Kunze G, Kock M, Schlatter H, Gerberick GF, Blömeke B. 2010. Elicitation of the immune response to p-phenylenediamine in allergic patients: The role of dose and exposure time. Br J Dermatol 163(6):1205-11. PMID: 20795999

Bonifas J, Scheitza S, Clemens J, Blomeke B. 2010. Characterization of N-acetyltransferase 1 activity in human keratinocytes and modulation by para-phenylenediamine. J Pharmacol Exp Ther 334(1):318-26. PMID: 20406859

Schneider M, Tanaka-Nozaki M, Kato S, Blömeke B. 2010. Influence of 5-fluorouracil on ferrodoxin reductase mRNA splice variants in colorectal carcinomas. Oncol Lett 1(2):351-354. PMID: 22966307 

Bonifas J, Hennen J, Dierolf D, Kalmes M, Blömeke B. 2010. Evaluation of cytochrome p450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: implications for the development of in vitro techniques for predictive testing of contact sensitizers. Toxicol In Vitro 24(3):973-980. PMID: 20036732

Blömeke B, Wiesmüller GA. 2009. Haut-und allergische Reaktionen auf Umweltfaktoren. CME Dermatologie 4(3):168-182.

Blömeke B, Brans R, Coenraads P, Dickel H, Bruckner T, Hein D, Heesen M, Merk H, Kawakubo Y. 2009. Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes. Brit J Derm 161(5):1130-1135. PMID: 19663877

Buss A, Pech K, Roelver S, Blömeke B, Klotzsch C, Breuer S. 2009. Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection. BMC Neurol 9(1):40. PMID: 19664242

Meyer A, Blomeke B, Fischer K. 2009. Determination of p-phenylenediamine and its metabolites MAPPD and DAPPD in biological samples using HPLC-DAD and amperometric detection. J Chromatogr B Analyt Technol Biomed Life Sci 877(16-17):1627-33. PMID: 19409864

Lermen D, Blömeke B, Browne R, Clarke A, Dyce PW, Fixemer T, Fuhr GR, Holt WV, Jewgenow K, Lloyd RE, Lötters S, Paulus M, Reid GM, Rapoport DH, Rawson D, Ringleb J, Ryder OA, Spörl G, Schmitt T, Veith M, Müller P. 2009. Cryobanking of viable biomaterials: implementation of new strategies for conservation purposes. Mol Ecol 18(6):1030-1033. PMID: 19207252

Brans R, Skazik C, Merk HF, Blomeke B. 2009. Sensitisation to p-Phenylenediamine. Effects of metabolism and individual susceptibility. Hautarzt 60(1):26-31. PMID: 19099270

Skazik C, Grannemann S, Wilbers L, Merk HF, Coenraads PJ, Breuer S, Blomeke B. 2008. Reactivity of in vitro activated human T lymphocytes to p-phenylenediamine and related substances. Contact Dermatitis 59(4):203-11. PMID: 18844695

Moeller R, Lichter J, Blomeke B. 2008. Impact of para-phenylenediamine on cyclooxygenases expression and prostaglandin formation in human immortalized keratinocytes (HaCaT). Toxicology 249(2-3):167-75. PMID: 18571826

Blömeke B, Pietzsch T, Merk HF. 2008. Elicitation response characteristics to mono- and to N,N′-diacetyl-para-phenylenediamine. Contact Dermatitis 58(6):355-8. PMID: 18503685

Blömeke B, Golka K, Griefahn B, Roemer HC. 2008. Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis. J Toxicol Environ Health A 71(13-14):874-6. PMID: 18569588

Roemer HC, Weistenhofer W, Lohlein D, Geller F, Blomeke B, Golka K. 2008. N-acetyltransferase 1 in colon and rectal cancer cases from an industrialized area. J Toxicol Environ Health A 71(13-14):902-5. PMID: 18569593

Lichter J, Heckelen A, Fischer K, Blomeke B. 2008. Expression of N-acetyltransferase in monocyte-derived dendritic cells. J Toxicol Environ Health A 71(13-14):960-4. PMID: 18569602

Tietze C, Blomeke B. 2008. Sensitization assays: monocyte-derived dendritic cells versus a monocytic cell line (THP-1). J Toxicol Environ Health A 71(13-14):965-968. PMID: 18569603

Wiesmuller GA, Niggemann H, Weissbach W, Riley F, Maarouf Z, Dott W, Kunert HJ, Zerres K, Eggermann T, Blomeke B. 2008. Sequence variations in subjects with self-reported multiple chemical sensitivity (sMCS): a case-control study. J Toxicol Environ Health A 71(11-12):786-94. PMID: 18569577

Blömeke B, Brans R, Dickel H, Bruckner T, Erdmann S, Heesen M, Merk H, Coenraads PJ. 2009. Association between TNFA -308G/A polymorphism and sensitization to para-phenylenediamine: Case-control study. Allergy 64:279-283. PMID: 18384449

Kalmes M, Neumeyer A, Rio P, Hanenberg H, Fritsche E, Blömeke B. 2006. Impact of the arylhydrocarbon receptor on eugenol- and isoeugenol-induced cell cycle arrest in human immortalized keratinocytes (HaCaT). Biol Chem 387:1201-1207. PMID: 16972787

Majetschak M, Krehmeier U, Ostroverkh L, Blömeke B, Schafer M. 2005. Alterations in Leukocyte Function following Surgical Trauma: Differentiation of Distinct Reaction Types and Association with Tumor Necrosis Factor Gene Polymorphisms. Clin Diagn Lab Immunol 12(2):296-303. PMID: 15699425

Duisken M, Sandner F, Blomeke B, Hollender J. 2005. Metabolism of 1,8-cineole by human cytochrome P450 enzymes: identification of a new hydroxylated metabolite. Biochim Biophys Acta 1722(3):304-311. PMID: 15715982

Brans R, Dickel H, Bruckner T, Coenraads PJ, Heesen M, Merk HF, Blomeke B. 2005. MnSOD polymorphisms in sensitized patients with delayed-type hypersensitivity reactions to the chemical allergen para-phenylene diamine: A case-control study. Toxicology 212(2-3):148-54. PMID: 15951095

Grannemann S, Landt O, Breuer S, Blömeke B. 2005. LightTyper Assay with Locked-Nucleic-Acid-Modified Oligomers for Genotyping of the Toll-Like Receptor 4 Polymorphisms A896G and C1196T. Clin Chem 51(8):1523-5. PMID: 16040849

Duisken M, Benz D, Peiffer TH, Blomeke B, Hollender J. 2005. Metabolism of Delta(3)-carene by human cytochrome p450 enzymes: identification and characterization of two new metabolites. Curr Drug Metab 6(6):593-601. PMID: 1637967

Wiesmüller GA, Zerres K, Blömeke B, Weißbach W, Dott W, Eggermann T. 2004. Genetische Disposition und Multiple Chemische Sensivität (MCS): Stand des Wissens und Konsequenzen für die molekulargenetische Diagnostik. Umweltmed Forsch Prax:275-280.

Brans R, Laizane D, Khan A, Blomeke B. 2004. N-acetyltransferase 2 genotyping: an accurate and feasible approach for simultaneous detection of the most common NAT2 alleles. Clin Chem 50(7):1264-6. PMID: 15229163

Heesen M, Kunz D, Wessiepe M, van der Poll T, Zwinderman AH, Blomeke B. 2004. Rapid genotyping for tumor necrosis factor-alpha (TNF-alpha)-863C/A promoter polymorphism that determines TNF-alpha response. Clin Chem 50(1):226-8. PMID: 14709658

Tanaka-Nozaki M, Tajiri T, Tanaka N, Furukawa K, Takasaki H, Yoshimura K, Suzuki H, Naito Z, Sugizaki Y, Merk HF, Blomeke B, Kato S. 2003. Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival. Oncol Rep 10(5):1425-1429. PMID: 12883718

Heesen M, Wessiepe M, Kunz D, Vasickova K, Blomeke B. 2003. Rapid and reliable genotyping for the Toll-like receptor 4 A896G polymorphism using fluorescence-labeled hybridization probes in a real-time polymerase chain reaction assay. Clin Chim Acta 333(1):47-9. PMID: 12809734

Heesen M, Kunz D, Bachmann-Mennenga B, Merk HF, Bloemeke B. 2003. Linkage disequilibrium between tumor necrosis factor (TNF)-alpha-308 G/A promoter and TNF-beta NcoI polymorphisms: Association with TNF-alpha response of granulocytes to endotoxin stimulation. Crit Care Med 31(1):211-4. PMID: 12545017

Heesen M, Schippers EF, Bloemeke B, Kunz D, van Dissel JT. 2003. Cytokine response to endotoxin in individuals heterozygous for the Delta32 mutation of chemokine receptor CCR5. Cytokine 21(4):195-9. PMID: 12788308

Heesen M, Bloemeke B, Kunz D. 2003. The cytokine synthesis by heterozygous carriers of the Toll-like receptor 4 Asp299Gly polymorphism does not differ from that of wild type homozygotes. Eur Cytokine Netw 14(4):234-7. PMID: 14715415

Rodrigues-Lima F, Blomeke B, Sim E, Dupret JM. 2002. NAT-from bugs to brains. An overview of the 2nd International Workshop on the arylamine N-acetyltransferases. Pharmacogenomics J 2(3):152-5. PMID: 12082586

Sieben S, Kawakubo Y, Masaoudi TA, Merk HF, Blomeke B. 2002. Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones. J Allergy Clin Immunol 109(6 Pt 1):1005-11. PMID: 12063532

Majetschak M, Obertacke U, Schade FU, Bardenheuer M, Voggenreiter G, Bloemeke B, Heesen M. 2002. Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients. Clin Diagn Lab Immunol 9(6):1205-11. PMID: 12414751

Heesen M, Bloemeke B, Bachmann-Mennenga B, Kunz D. 2002. The CD14-260 C --> T promoter polymorphism co-segregates with the tumor necrosis factor-alpha (TNF-alpha)-308 G --> A polymorphism and is associated with the interleukin-1 beta (IL-1 beta) synthesis capacity of human leukocytes. Eur Cytokine Netw 13(2):230-3. PMID: 12101079

Heesen M, Bloemeke B, Heussen N, Kunz D. 2002. Can the interleukin-6 response to endotoxin be predicted? Studies of the influence of a promoter polymorphism of the interleukin-6 gene, gender, the density of the endotoxin receptor CD14, and inflammatory cytokines. Crit Care Med 30(3):664-9. PMID: 11990931

Heesen M, Obertacke U, Schade FU, Bloemeke B, Majetschak M. 2002. The interleukin-6 G(-174)C polymorphism and the ex vivo interleukin-6 response to endotoxin in severely injured blunt trauma patients. Eur Cytokine Netw 13(1):72-7. PMID: 11956023

Heesen M, Bloemeke B, Schade U, Obertacke U, Majetschak M. 2002. The -260 C-->T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients. Intensive Care Med 28(8):1161-3. PMID: 12185442

Sieben S, Kawakubo Y, Sachs B, Al Masaoudi T, Merk HF, Blömeke B. 2001. T cell responses to paraphenylenediamine and to its metabolites mono- and diacetyl-paraphenylenediamine. Int Arch Allergy Immunol 124:356-58.

Al Masaoudi T, Sieben S, Callahan CP, Merk HF, Blömeke B. 2001. Eugenol but Not Isoeugenol Induces CYPIA1 mRNA in Human Keratinocytes. Int Arch Allergy Immunol 124(1-3):309-311.

Vähäkangas KH, Bennett WP, Castrén K, Welsh JA, Khan MA, Blömeke B, Alavanja MC, Harris CC. 2001. p53 and K-ras mutations in lung cancers from former and never-smoking women. Cancer Res 61(11):4350-6. PMID: 11389059

Heesen M, Blomeke B, Schluter B, Heussen N, Rossaint R, Kunz D. 2001. Lack of association between the -260 C-->T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels. Intensive Care Med 27(11):1770-5. PMID: 11810121

Sieben S, Hertl M, Al Masaoudi T, Merk HF, Blomeke B. 2001. Characterization of T cell responses to fragrances. Toxicol Appl Pharmacol 172(3):172-8. PMID: 11312644

Heesen M, Kunz D, Rossaint R, Blomeke B. 2000. Real-time PCR assay with fluorescent hybridization probes for rapid genotyping of the CD14 promotor polymorphism. Clin Chem 46(11):1866-7.PMID: 11067836

Neemeshkanna S, Landt O, Merk HF, Blomeke B. 2000. Fluorogenic probes to detect the A(-444)C transversion in the leukotriene C4 synthase promoter [letter]. Clin Chem 46(9):1438-9.

Kawakubo Y, Merk HF, Masaoudi TA, Sieben S, Blomeke B. 2000. N-Acetylation of Paraphenylenediamine in Human Skin and Keratinocytes. J Pharmacol Exp Ther 292(1):150-5.

 

Sieben S, Blömeke B, Merk HF. 1999. Fragrances Between Allergic, Hypoallergic, and Irritant: In Vitro Studies. In: Elsner P, Merk HF, Maibach HI, editors. Cosmetics - Controlled Efficacy Studies and Regulation. Berlin: Springer.

Blömeke B, Sieben S, Spotter D, Landt O, Merk HF. 1999. Identification of N-acetyltransferase 2 genotypes by continuous monitoring of fluorogenic hybridization probes. Anal Biochem 275(1):93-7.

Blömeke B, Shields PG. 1999. Laboratory methods for the determination of genetic polymorphisms in humans. IARC Sci Publ (148):133-47.

Sieben S, Baron JM, Blomeke B, Merk HF. 1999. Multiple cytochrome P450-isoenzymes mRNA are expressed in dendritic cells. Int Arch Allergy Immunol 118(2-4):358-61.

Bennett WP, Alavanja MC, Blomeke B, Vahakangas KH, Castren K, Welsh JA, Bowman ED, Khan MA, Flieder DB, Harris CC. 1999. Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women. J Natl Cancer Inst 91(23):2009-14.

Blomeke B, Bennett WP, Harris CC, Shields PG. 1997. Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes. Carcinogenesis 18(6):1271-5.

Blömeke B, Greenblatt MJ, Doan VD, Bowman ED, Murphy SE, Chen CC, Kato S, Shields PG. 1996. Distribution of 7-alkyl-2'-deoxyguanosine adduct levels in human lung. Carcinogenesis 17(4):741-8.

Ambrosone CB, Kato S, Bowman ED, Harrington AM, Blomeke B, Freudenheim JL, Graham S, Marshall JR, Vena JE, Brasure JR, Shields PG. 1996. Molecular epidemiology of lung and breast cancer. Eur J Cancer Prev 5(5):391-2.

Kato S, Bowman ED, Harrington AM, Blomeke B, Shields PG. 1995. Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. J Natl Cancer Inst 87(12):902-7.

Kato S, Petruzzelli S, Bowman ED, Turteltaub KW, Blomeke B, Weston A, Shields PG. 1993. 7-Alkyldeoxyguanosine adduct detection by two-step HPLC and the 32P- postlabeling assay. Carcinogenesis 14(4):545-50.

Blömeke B, Poginsky B, Schmutte C, Marquardt H, Westendorf J. 1992. Formation of genotoxic metabolites from anthraquinone glycosides, present in Rubia tinctorum L. Mutat Res 265(2):263-72.

Poginsky B, Westendorf J, Blomeke B, Marquardt H, Hewer A, Grover PL, Phillips DH. 1991. Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L. Carcinogenesis 12(7):1265-71.